Sodium Hydroxide → HCID 67685624, compound

HRID 1078505Notes

Reaction equation

HRID 1078505 reaction equation
[CH3:1][C:2]1([C:8]2[CH:9]=[C:10](/[C:16](/[CH3:29])=[CH:17]\[C:18]3[CH:28]=[CH:27][C:21]([C:22]([O:24]CC)=[O:23])=[CH:20][CH:19]=3)[CH:11]=[CH:12][C:13]=2[O:14][CH3:15])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[OH-].[Na+]>CO>[CH3:1][C:2]1([C:8]2[CH:9]=[C:10](/[C:16](/[CH3:29])=[CH:17]\[C:18]3[CH:19]=[CH:20][C:21]([C:22]([OH:24])=[O:23])=[CH:27][CH:28]=3)[CH:11]=[CH:12][C:13]=2[O:14][CH3:15])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67685739HCID 67685739, compound

Product 1

HCID 67685624HCID 67685624, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
40 °C

Procedure

0.69 g (1.76 mmol) of the ester obtained in Example 31, in 15 ml of methanol, is treated with 1.58 g of sodium hydroxide. The reaction mixture is stirred at 40° C. for 2 h. After the same treatment as in Example 8, 462 mg (72%) of the expected derivative are isolated, which derivative melts at 175°-176° C.

Workup

  1. customAfter the same treatment as in Example 8, 462 mg (72%) of the expected derivative are isolated

Sources & evidence

ORD record
ord-7e2034301a3c40f9aa4e79f59caac39c
Source dataset
uspto-grants-1996_08
Patent number
US05547983

Reaction notes

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