HCID 19429711, compound → HCID 19429703, compound

HRID 1078510Notes

Reaction equation

HRID 1078510 reaction equation
[C:1]12([C:11]3[CH:12]=[C:13]([C:24]4[CH:25]=[C:26]5[C:31](=[CH:32][CH:33]=4)[CH:30]=[C:29]([C:34]([O:36]CC4C=CC=CC=4)=[O:35])[CH:28]=[CH:27]5)[CH:14]=[CH:15][C:16]=3[CH2:17][CH2:18][CH2:19][O:20][C:21](=[O:23])[CH3:22])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>O1CCOCC1.[Pd]>[C:1]12([C:11]3[CH:12]=[C:13]([C:24]4[CH:25]=[C:26]5[C:31](=[CH:32][CH:33]=4)[CH:30]=[C:29]([C:34]([OH:36])=[O:35])[CH:28]=[CH:27]5)[CH:14]=[CH:15][C:16]=3[CH2:17][CH2:18][CH2:19][O:20][C:21](=[O:23])[CH3:22])[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2

Participants

4

Reactant 1

HCID 19429711HCID 19429711, compound

Product 1

HCID 19429703HCID 19429703, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

1.77 g (3.1 mmol) of the diester obtained in Example 44, in solution in 50 ml of dioxane, are hydrogenated in the presence of 530 mg of palladium on carbon (10%) at 50° C., under a hydrogen pressure of 7 bar. After the same treatment as in Example 5 followed by a recrystallization from ethyl acetate, 1.13 g (83%) of the expected product are isolated, which product melts at 260° C.

Workup

  1. customAfter the same treatment as in Example 5 followed by a recrystallization from ethyl acetate, 1.13 g (83%) of the expected product
  2. customare isolated

Sources & evidence

ORD record
ord-87917fe200874e20bb42469a0ab3ec58
Source dataset
uspto-grants-1996_08
Patent number
US05547983

Reaction notes

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