HCID 19429695, compound → HCID 19429716, compound

Participants

Reaction Steps

1.25 g (2.1mmol) of the benzyl ester obtained in Example 48, in 50 ml of dioxane, are hydrogenated at 70° C. in the presence of 190 mg of palladium on carbon (10%), under a hydrogen pressure of 7 bar, for 12 h. After the same treatment as in Example 5 followed by a recrystallization from the ethyl acetate/hexane mixture, 742 mg (71%) of the expected derivative are isolated, which derivative melts at 272° C.

Provenance & Evidence