HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1078557Generated: November 1, 2026
Ethyl 4-bromo-2-butenoate → Ethyl 3,4-dihydro-2H-1,4-benzoxazine-3-acetate
https://huagongshe.com/reaction/1078557
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl 4-bromo-2-butenoate | HCID 98102 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 2,2,2-trifluoro-N-(2-hydroxyphenyl)acetamide | HCID 13278497 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 3,4-dihydro-2H-1,4-benzoxazine-3-acetate | HCID 10632771 | — |
Reaction Steps
650 ml of ethanol are introduced into a 3 l reactor, with magnetic stirring, cooled to 0° C., 5.9 g (0.259 mol) of sodium are added slowly, in small portions, followed by successive dropwise addition of 53 g (0.259 mol) of N-(2-hydroxyphenyl)trifluoroacetamide and 50 g (0.259 mol) of 75% pure ethyl 4-bromo-2-butenoate, and the mixture is heated at 80° C. for 1.5 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05550125 |
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| Source dataset | uspto-grants-1996_08 |
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| ORD ID | ord-e248054094164b0885e21f23e5b4ed2d |
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| Source note | uspto-grants-1996_08 |
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