Ethyl 4-bromo-2-butenoate → HCID 54054098, compound

Participants

Reaction Conditions

Reaction Steps

370 ml of ethanol are introduced into a 1 l reactor, with magnetic stirring, cooled to 0° C., and 3.5 g (0.146 mol) of sodium are introduced slowly, in small portions, followed by successive dropwise addition of 32.54 g (0.146 mol) of N-(5-fluoro-2-hydroxyphenyl)trifluoroacetamide and 28.18 g (0.146 mol) of 75% pure ethyl 4-bromo-2-butenoate, and the mixture is heated at 80° C. for 3 h.

Provenance & Evidence