Carbon Dioxide → HCID 53903889, compound

Participants

Reaction Steps

145 ml of tetrahydrofuran are introduced into a 1 l reactor which is cooled with a mixture of ice and salt, and, under an argon atmosphere, 5.9 g (0.153 mol) of lithium aluminium hydride are added, followed by dropwise addition of 23.22 g (0.097 mol) of ethyl (±)-6-fluoro-3,4-dihydro-2H-1,4-benzoxazine-3-acetate dissolved in 145 ml of tetrahydrofuran, and the mixture is stirred for 2.5 h. The reactor is cooled with a mixture of cardice and acetone, 45 ml of water and 23 ml of 1N sodium hydroxide are added dropwise and stirring is continued for 0.5 h.

Provenance & Evidence