Ethyl 4-bromo-2-butenoate → HCID 53889352, compound

Participants

Reaction Conditions

Reaction Steps

450 ml of ethanol are introduced into a 1 l reactor, with magnetic stirring, cooled to 0° C., and 7 g (0.32 mol) of sodium are added slowly, in small portions, followed by successive dropwise addition of 37.94 g (0.16 mol) of N-(2-hydroxy-5-methoxyphenyl)trifluoroacetamide and 41.2 g (0.16 mol) of pure ethyl 4-bromo-2-butenoate, and the mixture is heated at 80° C. for 2 h.

Provenance & Evidence