1-(2-Methoxyphenyl)piperazine → 7-methoxy-3-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-4-methyl-2H-1-benzopyran-2-one

HRID 1078575Notes

Reaction equation

HRID 1078575 reaction equation
CS(O[CH2:6][CH2:7][C:8]1[C:9](=[O:21])[O:10][C:11]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:12]=2[C:13]=1[CH3:14])(=O)=O.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>C(O)C.CC(OC)(C)C>[CH3:20][O:19][C:17]1[CH:16]=[CH:15][C:12]2[C:13]([CH3:14])=[C:8]([CH2:7][CH2:6][N:33]3[CH2:32][CH2:31][N:30]([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4[O:23][CH3:22])[CH2:35][CH2:34]3)[C:9](=[O:21])[O:10][C:11]=2[CH:18]=1

Participants

4

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 152289603-[2-(methanesulphonyloxy)ethyl]-7-methoxy-4-methyl-2H-1-benzopyran-2-one

Product 1

HCID 152289617-methoxy-3-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-4-methyl-2H-1-benzopyran-2-oneYield 29%

Reagents, catalysts & solvents 1

HCID 18957737HCID 18957737, compoundSolvent

Procedure

Process A; starting materials: 3-[2-(methanesulphonyloxy)ethyl]-7-methoxy-4-methyl-2H-1-benzopyran-2-one (Example 26) and 1-(2-methoxyphenyl)piperazine; yield 29%; m.p. 129°-130° C. (from ethanol/TBME).

Sources & evidence

ORD record
ord-4c0eeb48de5c42588cf00014acd73110
Source dataset
uspto-grants-1996_08
Patent number
US05550129

Reaction notes

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