Ethanesulfonic acid → HCID 19428157, compound

Participants

Reaction Steps

Alternative process: 1.3 g (3.1 mmol) of 6-hydroxy-7-methoxy-3-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-4-methyl-2H-1-benzopyran-2-one (Example 2), two equivalents of sodium hydroxide and 2.5 equivalents of ethanesulphonic acid are dissolved in water/ethanol and stirred for 60 hours at room temperature. The reaction product is taken up in chloroform, washed with dilute sodium hydroxide and with water, dried over sodium sulphate, and the solvent is removed under reduced pressure. 0.94 g (59%) of pale yellow crystals with a melting point of 148°-150° C. (from ethanol/TBME) are obtained by column chromatography over silica gel (solvent: acetone/petroleum ether 1/1).

Provenance & Evidence