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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1078584Generated: November 4, 2026

N-(2-Methoxyphenyl)piperazine hydrochloride → 7,8-dimethoxy-3-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-4-methyl-2H-1-benzopyran-2-one

https://huagongshe.com/reaction/1078584

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(2-Methoxyphenyl)piperazine hydrochlorideHCID 9899402—
Reactant3-(2-chloroethyl)-7,8-dimethoxy-4-methyl-2H-1-benzopyran-2-oneHCID 19428139—
SolventTBME isopropanolHCID 86616950—
Product7,8-dimethoxy-3-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-4-methyl-2H-1-benzopyran-2-oneHCID 194281356%

Reaction Steps

Process A; starting materials: 3-(2-chloroethyl)-7,8-dimethoxy-4-methyl-2H-1-benzopyran-2-one (Example 32) and 1-(2-methoxyphenyl)piperazine hydrochloride; yield 6%; m.p. 146°-148° C. (from isopropanol/TBME).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05550129
Source datasetuspto-grants-1996_08
ORD IDord-067276304eec4b7384672ba561faf0af
Source noteuspto-grants-1996_08