1-(2-Methoxyphenyl)piperazine → 5,7-dimethoxy-3-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-4-methyl-2H-1-benzopyran-2-one

HRID 1078591Notes

Reaction equation

HRID 1078591 reaction equation
CS(O[CH2:6][CH2:7][C:8]1[C:9](=[O:23])[O:10][C:11]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[C:15]([O:21][CH3:22])[C:12]=2[C:13]=1[CH3:14])(=O)=O.[CH3:24][O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>C(O)C>[CH3:22][O:21][C:15]1[C:12]2[C:13]([CH3:14])=[C:8]([CH2:7][CH2:6][N:35]3[CH2:34][CH2:33][N:32]([C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=4[O:25][CH3:24])[CH2:37][CH2:36]3)[C:9](=[O:23])[O:10][C:11]=2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=1

Participants

4

Reactant 2

HCID 13461-(2-Methoxyphenyl)piperazineHCID 194281303-[2-(methanesulphonyloxy)ethyl]-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one

Product 1

HCID 194281545,7-dimethoxy-3-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-4-methyl-2H-1-benzopyran-2-oneYield 71%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Process B; starting materials: 3-[2-(methanesulphonyloxy)ethyl]-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one (Example 35) and 1-(2-methoxyphenyl)piperazine; yield 71%; m.p. 140°-142° C. (from ethanol).

Sources & evidence

ORD record
ord-48902e2619854a1ea43711fd264fcd61
Source dataset
uspto-grants-1996_08
Patent number
US05550129

Reaction notes

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