4-Phenylpiperidin-4-ol → HCID 19428141, compound

HRID 1078598Notes

Reaction equation

HRID 1078598 reaction equation
Cl[CH2:2][CH2:3][C:4]1[C:5](=[O:19])[O:6][C:7]2[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[C:11]([O:17][CH3:18])[C:8]=2[C:9]=1[CH3:10].[OH:20][C:21]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>C(OCC)(=O)C.C(O)C>[OH:20][C:21]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:26][CH2:25][N:24]([CH2:2][CH2:3][C:4]2[C:5](=[O:19])[O:6][C:7]3[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[C:11]([O:17][CH3:18])[C:8]=3[C:9]=2[CH3:10])[CH2:23][CH2:22]1

Participants

4

Reactant 2

HCID 963874-Phenylpiperidin-4-olHCID 194281613-(2-chloroethyl)-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one

Product 1

HCID 19428141HCID 19428141, compoundYield 41%

Reagents, catalysts & solvents 1

HCID 21584252Ethanol ethylacetateSolvent

Procedure

Process B; starting materials: 3-(2-chloroethyl)-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one (Example 39) and 4-hydroxy-4-phenylpiperidine; yield 41%; m.p. 177.5°-179° C. (from ethyl acetate/ethanol).

Sources & evidence

ORD record
ord-d4a05318e513484190e17d5e27b76f06
Source dataset
uspto-grants-1996_08
Patent number
US05550129

Reaction notes

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