HuagongsheHuagongshe Chemistry Print Report · For research reference only
o-(1-Piperazinyl)phenol → 3-{2-[4-(2-hydroxyphenyl)-1-piperazinyl]-ethyl}-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | o-(1-Piperazinyl)phenol | HCID 70530 | — |
| Reactant | 3-(2-chloroethyl)-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one | HCID 19428161 | — |
| Solvent | HCID 18957737 | HCID 18957737 | — |
| Product | 3-{2-[4-(2-hydroxyphenyl)-1-piperazinyl]-ethyl}-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one | HCID 19428128 | 22% |
Reaction Steps
Process B; starting materials: 3-(2-chloroethyl)-5,7-dimethoxy-4-methyl-2H-1-benzopyran-2-one (Example 39) and 1-(2-hydroxyphenyl)piperazine; yield 22%; m.p. 164°-165° C. (from ethanol/TBME).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05550129 |
| Source dataset | uspto-grants-1996_08 |
| ORD ID | ord-851924c6e70b4b3e97f50054c95a4bad |
| Source note | uspto-grants-1996_08 |