Methyl iodide → HCID 19428168, compound

Participants

Reaction Steps

Alternative method: 100.0 g (423 mmol) of 5,7-dihydroxy-3-(2-hydroxyethyl)-4-methyl-2H-1-benzopyran-2-one (Example 49), 175.5 g (1270 mmol) of potassium carbonate and 150.2 g (1058 mmol) of methyl iodide are stirred under reflux for 4 hours in 1800 ml of ethanol. The solution is filtered, evaporated, extracted with chloroform, and the organic phase is washed with water, dried with Na2SO4 and re-evaporated. Yield 49.3 g (44%); m.p. 148°-150° C. (from isopropanol/TBME).

Provenance & Evidence