Acetic Acid → HCID 70050847, compound

Participants

Reaction Steps

A mixture of 1.3 g of (S)-4-(N-benzyloxycarbonyl-L-tyrosyl)-3 -methoxycarbonylmethyl-2-oxopiperazine- 1-acetic acid tert-butyl ester thus obtained, 300 mg of 10% palladium-carbon, 180 mg of acetic acid and 20 ml of methanol was stirred for 30 minutes in hydrogen streams. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to afford 1.0 g of (S)-4-L-tyrosyl-3-methoxycarbonylmethyl-2-oxo-piperazine-1-acetic acid tert-butyl ester acetate as a colorless oily product. This product can be used in the subsequent reaction without purification.

Provenance & Evidence