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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1078618Generated: October 26, 2026

Z-Ser(tBu)-OH → (S)-3-Tert-Butoxymethyl-2-Oxopiperazine-1-Acetic Acid

https://huagongshe.com/reaction/1078618

Reaction equation

Participants

RoleNameHCIDCharge
ReactantZ-Ser(tBu)-OHHCID 1715617—
ReactantN(2,2-dimethoxyethyl) glycine tert-butyl esterHCID 10846528—
Product(S)-3-Tert-Butoxymethyl-2-Oxopiperazine-1-Acetic AcidHCID 67743622—

Reaction Steps

In substantially the same manner as in Reference Example 2, the title compound was synthesized from N(2,2-dimethoxyethyl) glycine tert-butyl ester and N-benzyloxycarbonyl-O-tert-butyl-L-serine. M.p. 178°-180° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05550131
Source datasetuspto-grants-1996_08
ORD IDord-60198545593146f08c9dff6306f04cc8
Source noteuspto-grants-1996_08