Sodium Iodide → HCID 53656531, compound

Participants

Reaction Steps

In 7.39 ml of N,N-dimethylformamide were dissolved 2.0 g of (S)-4-(N-benzyloxycarbonyl-O-methyl-L-tyrosyl)-3-methoxycarbonylmethyl-2-oxopiperazine-1-acetic acid, 83,0 mg of sodium iodide and 563 μl of N,N-dimethylaminocarbonylmethyl chloride. To the solution was added 772 μl of triethylamine while stirring at room temperature. The mixture was stirred for 6 hours, to which was then added water. The mixture was shaken with ethyl acetate for extraction. The organic layer was concentrated under reduced pressure. The residue was purified by means of a silica gel chromatography (methylene chloride/methanol =13/1) to give 1.57 g (68.0%) of the title compound as a colorless oily product.

Provenance & Evidence