Potassium Hydroxide → HCID 22909661, compound

HRID 1078637Notes

Reaction equation

HRID 1078637 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][C:17]([S:20][CH3:21])=[CH:16][CH:15]=3)=[CH:12][C:11]([C:22]([O:24]CC)=[O:23])=[N:10]2)=[CH:5][CH:4]=1.[OH-].[K+]>CO>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][C:17]([S:20][CH3:21])=[CH:16][CH:15]=3)=[CH:12][C:11]([C:22]([OH:24])=[O:23])=[N:10]2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 10666727HCID 10666727, compound

Product 1

HCID 22909661HCID 22909661, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of ethyl 1-(4-methoxyphenyl)-5-[4-(methylthio)phenyl]pyrazole-3-carboxylate (10.2 g) and potassium hydroxide (3.7 g) in methanol (60 ml) was refluxed for 30 minutes. The solvent was evaporated, and the residue was dissolved in water and washed with toluene. The aqueous layer was acidified, and the precipitates were collected and washed with ethyl acetate to give crystals of 1-(4-methoxyphenyl)-5-[4-(methylthio)phenyl]pyrazole-3-carboxylic acid. (8.8 g).

Workup

  1. temperaturewas refluxed for 30 minutes
  2. customThe solvent was evaporated
  3. dissolutionthe residue was dissolved in water
  4. washwashed with toluene
  5. customthe precipitates were collected
  6. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-87c0218163d240c58a22b197eca29024
Source dataset
uspto-grants-1996_08
Patent number
US05550147

Reaction notes

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