関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 1,3-Butanedione, 4,4,4-trifluoro-1-[4-(methylthio)phenyl]- | HCID 10730170 | — |
| 反応物 | 4-Cyanophenylhydrazine Hydrochloride | HCID 16212962 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(4-Cyanophenyl)-5-[4-(methylthio)phenyl]-3-(trifluoromethyl)pyrazole | HCID 22909697 | 101.4% |
反応手順
A mixture of 1-[4-(methylthio)phenyl]-4,4,4-trifluorobutane-1,3-dione (1.8 g) and 4-cyanophenylhydrazine hydrochloride (1.2 g) in acetic acid (30 ml) and N,N-dimethylformamide (1 ml) was stirred at 110° C. for 3 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The extract was washed with water, dried over anhydrous magnesium sulfate, and evaporated to give a brown powder of 1-(4-cyanophenyl)-5-[4-(methylthio)phenyl]-3-(trifluoromethyl)pyrazole (2.5 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05550147 |
|---|
| 出典データセット | uspto-grants-1996_08 |
|---|
| ORD ID | ord-a2dd2b517c4f4f35b1a29dbc7943f319 |
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| 出典メモ | uspto-grants-1996_08 |
|---|
