Sodium Hydroxide → HCID 22909673, compound

Participants

Reaction Steps

A mixture of ethyl 4-{5-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1-pyrazolyl}phenoxyacetate (1.7 g), 10% sodium hydroxide (10 ml) in tetrahydrofuran (10 ml) and ethanol (40 ml) was refluxed for 3 hours. The solvent was evaporated, and the residue was dissolved in water and acidified with hydrochloric acid. The precipitates were filtered and recrystallized from a mixture of tetrahydrofuran, ethanol, and isopropyl ether to give 4-{5-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1-pyrazolyl}phenoxyacetic acid (1.1 g).

Provenance & Evidence