Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formamide | HCID 713 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 22909684 | HCID 22909684 | — |
| Product | HCID 22909698 | HCID 22909698 | — |
Reaction Steps
A mixture of ethyl 1-(4-carboxyphenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole-3-carboxylate (3.9 g) and sodium methoxide (3 g) in formamide (40 ml) was stirred at 45° C. for 3 hours. The mixture was poured into a mixture of ice-water and hydrochloric acid. The precipitates were collected, washed with water, and dried to give crystals of 1-(4-carboxyphenyl)-5-[4-(methylsulfonyl)phenyl]-pyrazole-3-carboxamide (3.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05550147 |
|---|
| Source dataset | uspto-grants-1996_08 |
|---|
| ORD ID | ord-0c9c8d20b746478a974c95d68ed34b44 |
|---|
| Source note | uspto-grants-1996_08 |
|---|
