Ethanol → Ethyl (3-Hydroxyphenyl)acetate

Participants

Reaction Steps

A mixture of 100 g (0.658 mol) of 3-hydroxyphenylacetic acid, 6.0 ml concentrated sulfuric acid and 800 ml of ethanol was refluxed through a soxhlet with 3A molecular sieves for 3 hours. The reaction was cooled and concentrated to an oil on a rotovapor. The residue was added to 500 ml ice cold saturated sodium bicarbonate and 1 liter of ether. The ether extract was dried over magnesium sulfate and evaporated to give 116 g (98%) of ethyl 3-hydroxyphenylacetate as an oil.

Provenance & Evidence