HCID 10692325, compound → HCID 22865010, compound

Participants

Reaction Steps

To a solution of (2S,4R)-N-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-[(E)-2-ethoxycarbonylvinyl]pyrrolidine (29 g, 50 mmol) in ethanol (500 ml) was added 10% palladium-carbon catalyst (5 g), and the mixture was stirred under a hydrogen atmosphere at room temperature for 2 h. To the mixture was added an additional 10% palladium-carbon catalyst (2 g), and the mixture was stirred for 1.5 h under the same condition. The catalyst was filtered off, and the filtrate was concentrated in vacuo. The residue was subjected to silica gel column chromatography (heptane-ethyl acetate) to give (2S,4R)-N-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-(2-ethoxycarbonyl)ethylpyrrolidine (15.62 g, yield: 78%).

Provenance & Evidence