Hydrochloric Acid → HCID 70274673, compound

Participants

Reaction Steps

To (2S,4R)-N-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-(2-methoxycarbonyl-1-oxoethyl)pyrrolidine (3.17 g, 7.9 mmol) was added a 3N hydrogen chloride--dioxane solution (30 ml). The mixture was stirred at room temperature for 2 h, and then concentrated in vacuo. Chloroform (20 ml) and methanol (20 ml) were added thereto, and the solvent was removed in vacuo. This operation was repeated twice, followed by being left overnight to obtain crude (2S,4R)-4-hydroxy-2-(2-methoxycarbonyl-1-oxoethyl)pyrrolidine monohydrochloride (1.76 g).

Provenance & Evidence