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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1078741Generated: October 30, 2026

6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride → alpha-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy alpha-[(4-methylphenyl)thio]-2(1H)-isoquinoline tridecanenitrile

https://huagongshe.com/reaction/1078741

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochlorideHCID 6456035—
Reactantalpha-(11-Bromoundecyl)-3,4-dimethoxy-alpha-[(4-methylphenyl)thio]benzeneacetonitrileHCID 10673824—
Productalpha-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy alpha-[(4-methylphenyl)thio]-2(1H)-isoquinoline tridecanenitrileHCID 1067568457.9%

Reaction Steps

The procedure of Example 3 is repeated using 3.14 g of α-(11-bromoundecyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile and 2.03 g of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride. This affords 2.2 g of the desired product as a light yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05550149
Source datasetuspto-grants-1996_08
ORD IDord-fd829e8731c64051bd60d5a4e5fa4de3
Source noteuspto-grants-1996_08