HRID1078745

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15623

Heliamine

C11H15NO2

反应SMILES：COc1ccc(C(C#N)(CCCCCCl)Sc2ccc(C)cc2)cc1OC

HCID10573255

未命名化合物

PRODUCTS

产物

反应SMILES：COc1ccc(C(C#N)(CCCCCC2CCc3cc4c(cc3N2)OCO4)Sc2ccc(C)cc2)cc1OC

HCID19042107

未命名化合物

收率 60.9%

PROCEDURE

实验过程

The procedure of Example 3 is repeated using 0.854 g of α-(5-chloropentyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]-benzeneacetonitrile and 0.677 g of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline. This affords 0.701 g of the desired product.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-f81cd9155af349bd93cd6d827d338e0a
来源数据集: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05550149
来源说明: uspto-grants-1996_08

反应SMILES

Cl[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([S:20][C:21]1[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=1)([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([O:18][CH3:19])[CH:11]=1)[C:8]#[N:9].C[O:29][C:30]1[CH:31]=[C:32]2[C:37](=[CH:38][C:39]=1[O:40][CH3:41])[CH2:36][NH:35][CH2:34][CH2:33]2>>[CH3:19][O:18][C:12]1[CH:11]=[C:10]([C:7]([S:20][C:21]2[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=2)([CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH:34]2[CH2:33][CH2:32][C:37]3[CH:38]=[C:39]4[O:40][CH2:41][O:29][C:30]4=[CH:31][C:36]=3[NH:35]2)[C:8]#[N:9])[CH:15]=[CH:14][C:13]=1[O:16][CH3:17]