HRID1078751

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc2c(cc1O[Si](C)(C)C(C)(C)C)CNCC2

HCID15285554

未命名化合物

结构：COc1ccc(C(C#N)Sc2ccc(C)cc2)c(CCCCCCl)c1OC

HCID67694021

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(C#N)(CCCCCN2CCc3cc(OC)c(O[Si](C)(C)C(C)(C)C)cc3C2)Sc2ccc(C)cc2)cc1OC

HCID15285555

未命名化合物

PROCEDURE

实验过程

The procedure of Example 3 is repeated using 2.5 g of α-(5-chloropentyl-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile and 2.54 g 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,2,3,4-tetrahydro-6-methoxyisoquinoline. This affords 1.2 g of the desired product as a light yellow oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a1625c9a69294f11aefeaf22742ab24b
来源数据集: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05550149
来源说明: uspto-grants-1996_08

反应 SMILES

ClCCCCC[C:7]1[C:12]([O:13][CH3:14])=[C:11]([O:15][CH3:16])[CH:10]=[CH:9][C:8]=1[CH:17]([S:20][C:21]1[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=1)[C:18]#[N:19].[CH3:28][C:29]([Si:32]([CH3:47])([CH3:46])[O:33][C:34]1[CH:43]=[C:42]2[C:37]([CH2:38][CH2:39][NH:40][CH2:41]2)=[CH:36][C:35]=1[O:44][CH3:45])([CH3:31])[CH3:30]>>[CH3:14][O:13][C:12]1[CH:7]=[C:8]([C:17]([S:20][C:21]2[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=2)([CH2:9][CH2:8][CH2:7][CH2:12][CH2:11][N:40]2[CH2:39][CH2:38][C:37]3[C:42](=[CH:43][C:34]([O:33][Si:32]([C:29]([CH3:28])([CH3:30])[CH3:31])([CH3:46])[CH3:47])=[C:35]([O:44][CH3:45])[CH:36]=3)[CH2:41]2)[C:18]#[N:19])[CH:9]=[CH:10][C:11]=1[O:15][CH3:16]