3,4-Dimethoxy-alpha[(4-methylphenyl)thio]benzeneacetonitrile → HCID 19042068, compound

HRID 1078755Notes

Reaction equation

HRID 1078755 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]([S:14][C:15]2[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=2)[C:12]#[N:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Br[CH2:23][CH2:24][CH2:25][CH2:26][CH:27]([Cl:29])[CH3:28]>>[Cl:29][CH:27]([CH3:28])[CH2:26][CH2:25][CH2:24][CH2:23][C:11]([S:14][C:15]1[CH:16]=[CH:17][C:18]([CH3:21])=[CH:19][CH:20]=1)([C:5]1[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)[C:12]#[N:13]

Participants

3

Reactant 2

HCID 105421673,4-Dimethoxy-alpha[(4-methylphenyl)thio]benzeneacetonitrileHCID 13791121HCID 13791121, compound

Product 1

HCID 19042068HCID 19042068, compoundYield 82%

Procedure

The procedure of Example 15 is repeated using 3.8 g of 3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile and 2.66 g of 1-bromo-5-chlorohexane. This affords 4.35 g of the desired product as a colorless oil.

Sources & evidence

ORD record
ord-9db02ea1c9774012ad2a172e31750eef
Source dataset
uspto-grants-1996_08
Patent number
US05550149

Reaction notes

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