HRID1078770

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID192723

6,7,8-Trimethoxy-1,2,3,4-tetrahydroisoquinoline

C12H17NO3

结构：COc1ccc(C(CCCCC(C)Br)Sc2ccc(C)cc2)cc1OC

HCID19042093

未命名化合物

HCID20074351

5,6-Dimethoxy-2,3-dihydro-1H-isoindole

C10H13NO2

PRODUCTS

生成物

结构：COc1ccc(C(CCCCCCN2CCc3cc(OC)c(OC)c(OC)c3C2)Sc2ccc(C)cc2)cc1OC

HCID10650882

未命名化合物

收率 65.7%

PROCEDURE

实验过程

The procedure of Example 49 is repeated using 5.31 g 4-[6-bromo-1-[(4-methylphenyl)thio]heptyl]-1,2-dimethoxybenzene, 3.29 g of 5,6-dimethoxyisoindoline and 2.65 g of 6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline. This affords 4.52 g of the desired product as a yellow oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-57bc418264f240a8bb93c0c290949b6b
来源数据集: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05550149
来源说明: uspto-grants-1996_08

反应 SMILES

Br[CH:2]([CH3:26])[CH2:3][CH2:4][CH2:5][CH2:6][CH:7]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[C:18]([O:24][CH3:25])[CH:17]=1)[S:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1.COC1C=C2C(=CC=1OC)CNC2.[CH3:40][O:41][C:42]1[CH:43]=[C:44]2[C:49](=[C:50]([O:54][CH3:55])[C:51]=1[O:52][CH3:53])[CH2:48][NH:47][CH2:46][CH2:45]2>>[CH3:25][O:24][C:18]1[CH:17]=[C:16]([CH:7]([S:8][C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][CH2:26][N:47]2[CH2:46][CH2:45][C:44]3[C:49](=[C:50]([O:54][CH3:55])[C:51]([O:52][CH3:53])=[C:42]([O:41][CH3:40])[CH:43]=3)[CH2:48]2)[CH:21]=[CH:20][C:19]=1[O:22][CH3:23]