4-Methylbenzenethiol → 1-[[(4-Methylphenyl)thio]methyl]-4-(trifluoromethoxy)benzene

HRID 1078780Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.[F:9][C:10]([F:21])([F:20])[O:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16]Cl)=[CH:14][CH:13]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:16][C:15]2[CH:18]=[CH:19][C:12]([O:11][C:10]([F:9])([F:20])[F:21])=[CH:13][CH:14]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 78114-Methylbenzenethiol

HCID 27772614-(Trifluoromethoxy)benzyl Chloride

Product 1

HCID 108516111-[[(4-Methylphenyl)thio]methyl]-4-(trifluoromethoxy)benzeneYield 80.1%

Procedure

The procedure of Example 87 is repeated using 11.8 g of p-thiocresol and 9.6 g of 4-(trifluoromethoxy)benzyl chloride. This affords 10.9 g of the desired product as white crystals.

Sources & evidence

ORD record: ord-714e3cf34dd94ad7b9ca0c90b18593a2
Source dataset: uspto-grants-1996_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05550149

Reaction notes

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