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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1078783Generated: October 25, 2026

2,3-dihydro-6-methoxy-1H-isoindol-5-ol → alpha-(3,4-Dimethoxyphenyl)-1,3-dihydro-5-hydroxy-6-methoxy-alpha-[(4-methylphenyl)thio]-2H-isoindole-2-heptanenitrile

https://huagongshe.com/reaction/1078783

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,3-dihydro-6-methoxy-1H-isoindol-5-olHCID 10241135—
Reactantalpha-(5-Bromopentyl)-3,4-dimethoxy-alpha-[(4-methylphenyl)thio]benzeneacetonitrileHCID 10527448—
Productalpha-(3,4-Dimethoxyphenyl)-1,3-dihydro-5-hydroxy-6-methoxy-alpha-[(4-methylphenyl)thio]-2H-isoindole-2-heptanenitrileHCID 1053030774.2%

Reaction Steps

The procedure of Example 49 is used with 0.209 g of 2,3-dihydro-6-methoxy-1H-isoindol-5-ol (Example 105) and 0.57 g of α-(5-bromopentyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile. This affords 0.5 g of the desired product as a gray foam.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05550149
Source datasetuspto-grants-1996_08
ORD IDord-87535cdce43944ed8b831c17fe2944d4
Source noteuspto-grants-1996_08