反应详情

The free base from 4.60 g of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, 3.63 g of [(7-bromo-1-phenylheptyl)thio]benzene, 50 ml of acetonitrile and 2.61 ml of ethyl diisopropylamine is heated at reflux temperature for 29 hours. The solvent is evaporated over night and the residue is partitioned between chloroform and aqueous ammonium hydroxide. The organic layer is dried and concentrated in vacuo to give 5.81 g of crude product. The residue is purified by chromatography (silica gel: chloroform/methyl alcohol) to give 1.73 g of the desired product.

1. temperatureat reflux temperature for 29 hours
2. customThe solvent is evaporated over night
3. customthe residue is partitioned between chloroform and aqueous ammonium hydroxide
4. customThe organic layer is dried
5. concentrationconcentrated in vacuo
6. customto give 5.81 g of crude product
7. customThe residue is purified by chromatography (silica gel: chloroform/methyl alcohol)