Water → Loribid

HRID 1078798Notes

Reaction equation

HRID 1078798 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]([C@@H:7]([NH2:24])[C:8]([NH:10][C@@H:11]2[C:18](=[O:19])[N:17]3[C@@H:12]2[CH2:13][CH2:14][C:15]([Cl:23])=[C:16]3[C:20]([OH:22])=[O:21])=[O:9])=[CH:5][CH:6]=1.C([O-:27])C.O>>[CH2:13]1[CH:12]2[CH:11]([NH:10][C:8]([C@H:7]([NH2:24])[C:4]3[CH:5]=[CH:6][CH:1]=[CH:2][CH:3]=3)=[O:9])[C:18](=[O:19])[N:17]2[C:16]([C:20]([OH:22])=[O:21])=[C:15]([Cl:23])[CH2:14]1.[OH2:27]

Participants

3

Reactant 2

HCID 962WaterHCID 86748663HCID 86748663, compound

Product 1

HCID 60746Loribid

Procedure

Loracarbef ethanolate, (4.0 g, 97.1% potency), was slurried in 56 ml of water (containing 0.004 eq sodium, ~0.02 g editate) at 50° C. for 2 hours. Within 30 minutes the slurry became very thick, indicating conversion to monohydrate. The product was vacuum filtered, washed with a minimum amount of water, and dried in a 40° C. vacuum oven. X-ray-confirmed as monohydrate.

Workup

  1. filtrationfiltered
  2. washwashed with a minimum amount of water
  3. customdried in a 40° C. vacuum oven

Sources & evidence

ORD record
ord-68d663e7ab6144ac9bdefd4fcd2885b0
Source dataset
uspto-grants-1996_08
Patent number
US05550231

Reaction notes

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