HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → Triphenylphosphine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | HCID 178514248 | HCID 178514248 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Triphenylphosphine | HCID 11776 | — |
| Product | Oxazoline | HCID 68157 | — |
Reaction Steps
Hydroxyamide IX is then subjected to cyclodehydration in an inert organic solvent (e.g., THF, acetonitrile or methylene chloride) under an inert atmosphere (e.g., argon) with triphenylphosphine (employing a molar ratio of IX:triphenylphosphine of about 0.5:1 to about 1:1) and carbon tetrachloride in the presence of an amine base (e.g., triethylamine or diisopropylethylamine) to form an oxazoline ##STR26##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05550248 |
| Source dataset | uspto-grants-1996_08 |
| ORD ID | ord-974a9ab5172f4fb897340ead5f1b2705 |
| Source note | uspto-grants-1996_08 |