Cyclopentylamine → HCID 19428501, compound

HRID 1078967Notes

Reaction equation

HRID 1078967 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[N:3]=1.ClC1N=C([NH:17][CH:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)C=C(Cl)N=1.C1(N)CCCC1>>[CH:18]1([NH:17][C:2]2[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[N:3]=2)[CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 2906CyclopentylamineHCID 19428525HCID 19428525, compound

Product 1

HCID 19428501HCID 19428501, compoundYield 35.2%

Procedure

Preparation of 2-cyclopentylamino-4,6-dichloroplrrimidine and 2,6-dichloro-4-cyclopentylaminopyrimidine 2,4,6-Trichloropyrimidine is reacted with cyclopentylamine as described in Example 2 to obtain the less polar 2-cyclopentylamino-4,6-dichloropyrimidine in a yield of 35.2%, m.p.: 48°-52° C.

Sources & evidence

ORD record
ord-e183fcc313fd4966a46d744ddb7e324a
Source dataset
uspto-grants-1996_08
Patent number
US05550240

Reaction notes

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