HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4,4,4-Trifluorobutanoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4,4,4-Trifluorobutanoic acid | HCID 2777085 | — |
| Solvent | Pentane | HCID 8003 | — |
| Product | 4,4,4-Trifluorobutanoyl chloride | HCID 15104474 | 76% |
Reaction Steps
101 ml of oxalyl chloride and 0.1 ml of dimethylformamide was added to a solution of thus obtained 131 g of the 4,4,4-trifluorobutyric acid in 1 liter of pentane, and the resultant solution was refluxed for three hours. Then the reaction solution was distilled to yield 112 g of 4,4,4-trifluorobutyryl chloride in a yield of 76%. (b.p. 103° C./760 mmHg)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05550258 |
| Source dataset | uspto-grants-1996_08 |
| ORD ID | ord-55bd835531eb48bbb0db736492563515 |
| Source note | uspto-grants-1996_08 |