Ammonia → 2-(Methylamino)benzamide
Reaction equation
[CH3:1][NH:2][C:3]1[C:4]([C:9](C(O)=O)=[O:10])=[CH:5][CH:6]=[CH:7][CH:8]=1.O.[NH3:15]>C(O)C>[C:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[NH:2][CH3:1])(=[O:10])[NH2:15]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
N-Methylisatic acid (10.0 g) is added gradually to water (140 ml) at room temperature and thereto is added dropwise aqueous ammonia (9.6 g). The mixture is warmed to 80° C. during 45 minutes, and ethanol is added thereto until the reaction mixture becomes colorless. Then, the reaction mixture is cooled to room temperature and the precipitated crystals are collected by filtration to give 2-carbamoyl-N-methylaniline (7.11 g) as colorless crystal.
Workup
- temperatureThen, the reaction mixture is cooled to room temperature
- filtrationthe precipitated crystals are collected by filtration
Sources & evidence
- ORD record
- ord-59cc749540bf4580b4c46a9c77e0561f
- Source dataset
- uspto-grants-1996_08
- Patent number
- US05550229
Reaction notes
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