Urea → 4-Nitrobenzamide

Participants

Reaction Conditions

Reaction Steps

83.5 g (0.50 mol) of 4-nitrobenzoic acid, 30.0 g (0.50 mol) of urea and 1 g of phosphoric acid are heated in 250 ml of mesitylene with stirring at from 160° to 162° C. for 8 h. After cooling to 25° C. the solid is filtered off with suction and is washed with 25 ml of mesitylene. The filter cake is introduced into 250 ml of water and the mixture is adjusted to a pH of 12 with aqueous sodium hydroxide solution and subjected to steam distillation. Subsequently the solid is filtered off with suction and is dried at 100° C. 52.0 g of 4-nitrobenzamide are obtained having a melting point of from 193° to 195° C. This corresponds to a yield of 62.7% of theory.

Provenance & Evidence