Urea → 4-Nitrobenzamide

Participants

Reaction Conditions

Reaction Steps

83.5 g (0.50 mol) of 4-nitrobenzoic acid, 30.0 g (0.50 mol) of urea and 0.5 g of sulfamic acid are heated in 200 ml of dichlorobenzene with stirring at from 180° to 181° C. for 16 h. After cooling to 25° C. the solid is filtered off with suction and is washed with 50 ml of dichlorobenzene. The filter cake is introduced into 250 ml of water and the mixture is adjusted to a pH of 12 with aqueous sodium hydroxide solution and subjected to steam distillation. Subsequently the solid is filtered off with suction and is dried at 100° C. 40.6 g of 4-nitrobenzamide are obtained having a melting point of from 192° to 195° C. This corresponds to a yield of 48.9% of theory.

Provenance & Evidence