Sulfuric Acid → HCID 19428701, compound

HRID 1079099Notes

Reaction equation

HRID 1079099 reaction equation
[C:1]([S:5][CH2:6][C:7]([OH:17])([CH3:16])[P:8]([O:13][CH2:14][CH3:15])(=[O:12])[O:9][CH2:10][CH3:11])([CH3:4])([CH3:3])[CH3:2].S(=O)(=O)(O)O.ClCCl.[C:26](OC(=O)C)(=[O:28])[CH3:27]>>[C:26]([O:17][C:7]([CH3:16])([P:8]([O:9][CH2:10][CH3:11])(=[O:12])[O:13][CH2:14][CH3:15])[CH2:6][S:5][C:1]([CH3:4])([CH3:2])[CH3:3])(=[O:28])[CH3:27]

Participants

5

Reactant 4

HCID 1118Sulfuric AcidHCID 6344DichloromethaneHCID 7918Acetic AnhydrideHCID 19428703HCID 19428703, compound

Product 1

HCID 19428701HCID 19428701, compound

Conditions

Temperature
20 °C

Procedure

25.2 g (88.6 mmol) of diethyl 2-t-butylthio-1-hydroxy-1-methylethanephosphonate in 130 ml of acetic anhydride are treated with 1 ml of concentrated sulfuric acid, during which process the temperature of the solution rises from 20 to about 30° C. The mixture is subsequently stirred for 8 hours at 20° C., treated with 100 ml of dichloromethane and poured onto 300 ml of ice/water. The organic phase which is separated off is washed in succession with dilute hydrochloric acid, sodium hydrogen carbonate solution and water and dried over sodium sulfate, and the solvent is distilled off in vacuo.

Workup

  1. customrises from 20 to about 30° C
  2. customThe organic phase which is separated off
  3. washis washed in succession with dilute hydrochloric acid, sodium hydrogen carbonate solution and water
  4. dry with materialdried over sodium sulfate
  5. distillationthe solvent is distilled off in vacuo

Sources & evidence

ORD record
ord-a12f56eb1ace4e9a8e3d772ef86e3a91
Source dataset
uspto-grants-1996_08
Patent number
US05550276

Reaction notes

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