Acetone → HCID 131719512, compound

Participants

Reaction Steps

To a solution of 17-ethyl-1-hydroxy-12-[2'-(4"-triethylsilyloxy-4"-[3-phenyl-3-hydroxypropyl]-3"-methoxycyclohexyl)-1'-methylvinyl]-14-t-butyl-dimethylsilyloxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone (10 mg, 0.009 mmole) in CH2Cl2 (2 mL) was added NaOAc (1.6 mg, 0.020 mmole) and PCC (3 mg, 0.014 mmole). The reaction mixture was then stirred 1 hour at room temperature when reaction was complete (TLC, silica, 1:4 acetone: hexane). Celite was added and the reaction was diluted with diethyl ether. After 20 min. the reaction mixture was filtered and concentrated in vacuo to give 6 mg of the title compound. MASS:(FAB) 1158(M+ + Li).

Provenance & Evidence