HCID 131719518, compound → HCID 57231209, compound

Participants

Reaction Steps

A solution of 0.200 g (0.191 mmole) of 17-ethyl-1-hydroxy-12-[2'-(4"-hydroxy-4"-[benzyloxycarbonylmethyl]-3"-methoxycyclohexyl)-1'-methylvinyl]-14-tert-butyldimethylsilyloxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone in 5 mL of 10% (48% aqueous HF)-acetonitrile was stirred at room temperature for 16 h. The reaction was quenched by addition of 5 mL of trimethylethoxy-silane and the solution was concentrated under vacuum. The residue was purified by flash chromatography (silica gel, 1.5 cm×10 cm) using acetone-hexane and the product lyophilized from benzene to afford 0.148 g (82%) of the title compound as a colorless solid; MS (FAB) 946 (M+Li).

Provenance & Evidence