HCID 131719519, compound → HCID 56990074, compound

Participants

Reaction Steps

A solution of 220 mg (0.186 mmole) of 7-ethyl-1-hydroxy-12-[2'-(4"-triethylsilyloxy-4"-[3-(3,5-dimethylphenyl)-3-hydroxypropyl]-3"-methoxycyclohexyl)-1'-methylvinyl]-14-t-butyldimethylsilyloxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone in 10 mL of a 10% HF-acetonitrile solution was stirred at room temperature. After 18 h, the reaction was quenched with 5 mL of ethoxytrimethylsilane and the solution was concentrated. The oily residue was purified by HPLC (Waters RCM silica gel, 25×100 mm) using hexane-methyl t-butyl ether-acetonitrile (6:3:1) to afford 45 mg of the faster diastereomer as a white solid. MASS: 960 (M+Li)

Provenance & Evidence