Sodium Methoxide → HCID 15377769, compound

HRID 1079281Notes

Reaction equation

HRID 1079281 reaction equation
[CH3:1][O:2][C:3]1[C:4](=[O:25])[O:5][C:6]2[CH:20]=[C:19]([O:21]C(=O)C)[CH:18]=[CH:17][C:7]=2[C:8]=1[O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C[O-].[Na+]>CO>[CH3:1][O:2][C:3]1[C:4](=[O:25])[O:5][C:6]2[CH:20]=[C:19]([OH:21])[CH:18]=[CH:17][C:7]=2[C:8]=1[O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 23366424HCID 23366424, compound

Product 1

HCID 15377769HCID 15377769, compoundYield 81.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 3.64 g of 3-methoxy-4-benzyloxy-7-acetoxy-2H-1-benzopyran -2-one (10.7 mmol) in 50 ml of methanol was added 0.58 g of sodium methoxide (10.7 mmol) and the mixture was stirred at room temperature for 1 hour. Then 2.31 g of Amberlyst-15 (Trademark: Organo corp.) was added, and the mixture was stirred at room temperature for 1 hour. Amberlyst-15 was filterd off, the filtrate was concentrated under reduced pressure. The precipitate was obtained during concentration and filtered to give 2.59 g of the title compound. (yield=77%)

Workup

  1. additionThen 2.31 g of Amberlyst-15 (Trademark: Organo corp.) was added
  2. stirringthe mixture was stirred at room temperature for 1 hour
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe precipitate was obtained during concentration
  5. filtrationfiltered

Sources & evidence

ORD record
ord-aa66e2a8dcc846c28d7f6ddfd07068b0
Source dataset
uspto-grants-1996_12
Patent number
US05580552

Reaction notes

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