Dimethyl Sulfoxide → HCID 86750039, compound

Participants

Reaction Steps

2-Nitrophenylglycine amide, 1 DMSO (500 mg, 1.83 mmol) was suspended in chloroform (20 ml) and triethylamine (390 μl, 2.80 mmol) was added. Subsequently benzoyl chloride (330 μl, 2.8 mmol) was added with stirring. The reaction was followed by TLC using as eluent: CH2Cl2 /MeOH/AcOH (85:10:5) and after 1 h at 20° C. the reaction mixture was treated with a saturated solution of NaHCO3, dried over anhydrous MgSO4 and evaporated to dryness. The product was recrystallized from absolute ethanol. Yield: 600 mg (77%); mp 178°-180° C., identified by 1H NMR spectroscopy. ##STR13##

Provenance & Evidence