Propionyl chloride → HCID 23366695, compound

HRID 1079328Notes

Reaction equation

HRID 1079328 reaction equation
[C:1](Cl)(=[O:4])[CH2:2][CH3:3].[S:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[CH2:10][NH:9][CH2:8][CH2:7]1>ClCCl>[C:1]([N:9]1[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[S:6][CH2:7][CH2:8]1)(=[O:4])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 62324Propionyl chlorideHCID 122691062,3,4,5-Tetrahydrobenzo[f][1,4]thiazepine

Product 1

HCID 23366695HCID 23366695, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of propionyl chloride (2.39 g) in dichloromethane (50 ml) was added dropwise at room temperature to a stirred solution of 2,3,4,5-tetrahydro-1,4-benzothiazepine (8.58 g, prepared as described in the first paragraph of Example 6 above) in dichloromethane (100 ml). The reaction mixture was stirred at room temperature for 45 minutes, washed with water, dried and the solvent was removed by evaporation. Purification of the residue by flash chromatography using dichloromethane/ethanol (98:2) as eluent gave 4-propionyl-2,3,4,5-tetrahydro-1,4-benzothiazepine as an oil. Yield 2.9 g.

Workup

  1. customprepared
  2. washwashed with water
  3. customdried
  4. customthe solvent was removed by evaporation
  5. customPurification of the residue by flash chromatography

Sources & evidence

ORD record
ord-d250e6afda724084a2ca684e2197efeb
Source dataset
uspto-grants-1996_12
Patent number
US05580866

Reaction notes

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