Triethylamine → HCID 23366684, compound

Participants

Reaction Steps

A solution of methanesulphonyl chloride (3.3 g) in dichloromethane (15 ml) was added dropwise at room temperature to a stirred solution of 2,3,4,5-tetrahydro-1,4-benzothiazepine (4.8 g, prepared as described in the first paragraph of Example 6 above) and triethylamine (2.9 g) in dichloromethane (100 ml). The reaction mixture was stirred at room temperature for one hour, washed with water, dried and the solvent was removed by evaporation. Purification of the residue by flash chromatography using dichloromethane as eluent gave 4-methylsulphonyl-2,3,4,5-tetrahydro-1,4-benzothiazepine which was recrystallised from hexane. Yield 3 g. (m.p. 98°-100° C.).

Provenance & Evidence