m-Chloroperbenzoic acid → HCID 10220802, compound

Participants

Reaction Steps

A solution of 3-chloroperbenzoic acid (1.4 g) in dichloromethane (200 ml) was added dropwise with cooling from 0° C. to -2° C. to a stirred solution of 4-methylsulphonyl-2,3,4,5-tetrahydro-1,4-benzothiazepine (2 g, prepared as Example 17 above) in dichloromethane (50 ml). The reaction mixture was stirred for 15 minutes, washed with water, dried and the solvent was removed by evaporation at reduced pressure. Purification of the residue by flash chromatography using dichloromethane/ethanol (95:5) as eluent gave 4-methylsulphonyl-2,3,4,5-tetrahydro-1,4-benzothiazepine 1-oxide, which was recrystallised from ethanol. Yield 1.65 g (m.p. 195°-197° C.).

Provenance & Evidence