6-Aminoquinoline → HCID 23366720, compound

HRID 1079350Notes

Reaction equation

HRID 1079350 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[N:22]=[CH:21][CH:20]=[CH:19]2>>[N+:12]([C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[N:22]=[CH:21][CH:20]=[CH:19]2)([O-:14])=[O:13]

Participants

3

Reactant 2

HCID 113736-AminoquinolineHCID 113562574-Chloro-6-nitroquinazoline

Product 1

HCID 23366720HCID 23366720, compoundYield 86%

Procedure

Using an analogous procedure to that described in Example 1, 4-chloro-6-nitroquinazoline was reacted with 6-aminoquinoline to give 6-nitro-4-(6-quinolylamino)quinazoline in 86% yield, m.p. >300° C.;

Sources & evidence

ORD record
ord-73ad802302284c5faae95684cf467a8a
Source dataset
uspto-grants-1996_12
Patent number
US05580870

Reaction notes

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