1H-Indazol-5-amine → HCID 23366763, compound

HRID 1079354Notes

Reaction equation

HRID 1079354 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:15][C:16]1[CH:17]=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][N:20]=[CH:19]2>>[ClH:1].[NH:21]1[C:22]2[C:18](=[CH:17][C:16]([NH:15][C:2]3[C:11]4[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-:14])=[O:13])[CH:10]=4)[N:5]=[CH:4][N:3]=3)=[CH:24][CH:23]=2)[CH:19]=[N:20]1

Participants

3

Reactant 2

HCID 880121H-Indazol-5-amineHCID 113562574-Chloro-6-nitroquinazoline

Product 1

HCID 23366763HCID 23366763, compoundYield 68%

Procedure

Using an analogous procedure to that described in Example 1, 4-chloro-6-nitroquinazoline was reacted with 5-amino-1H-indazole to give in turn 4-(1H-indazol-5-ylamino)-6-nitroquinazoline hydrochloride in 68% yield, m.p. 289°-291° C., and the free base in quantitative yield.

Sources & evidence

ORD record
ord-a382c0baf8224a55862e129ca14f9d72
Source dataset
uspto-grants-1996_12
Patent number
US05580870

Reaction notes

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